HRT Users to Discuss Risks and Benefits at Their Next Routine Appointment

Women who are current or past users of hormone replacement therapy (HRT) to treat symptoms of the menopause are reminded to be vigilant for signs of breast cancer, even after stopping HRT


This is because a new study, published by The Lancet, has confirmed that women who use HRT for longer than 1 year have a higher risk of breast cancer than women who never use HRT. This known risk of breast cancer gets lower once HRT is stopped, but the new study shows some increased risk remains for more than 10 years compared to women who have never used HRT. The increased risk of breast cancer is seen with all types of HRT, except for topical HRT applied directly onto or into the vagina.


There is no need for urgent action but women who use, or are planning to use, HRT should be aware of these new findings when considering their HRT use at their next routine appointment. Women who have previously used HRT should be vigilant for signs of breast cancer and see a doctor if they notice any changes in their breasts. It is also important for all women to go to breast screening when invited.


The MHRA advises that HRT should only be initiated for relief of menopausal symptoms that adversely affect quality of life.


Women should use the lowest effective dose of HRT for the shortest duration and HRT should only be continued as long as the benefit in alleviating menopausal symptoms outweighs the risks associated with treatment. In all cases, a careful appraisal of all the risks and benefits should be undertaken regularly, as a woman’s need for treatment and chance of side effects changes over time. Each women’s risk will depend on what type of HRT is used and how long it is used for. Your doctor or nurse can tell you more about your risks.


Sarah Branch, Deputy Director of MHRA’s Vigilance and Risk Management of Medicines (VRMM) Division said:

“Women should be aware of this new information, so that it can be considered with the other risks and benefits of using HRT.


“The menopause can have unpleasant side effects and HRT products can be effective in helping to ease the symptoms.


“No medicine is completely without risk, but it is important for women to be able to make an informed decision about the risks and benefits that are appropriate for them.


“If you have any questions please talk to your healthcare professional.


“The Medicines and Healthcare products Regulatory Agency (MHRA) is communicating this new evidence to patients and healthcare professionals.”

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